Try making a taper point screw. Just find a regular hex head bolt that is the same pitch as the over sized screw you have now and try to grind down a proper taper point. It will seat into the hole and should seal it. Either the over sized screw doesn't have the same diameter at the point as the original hole, or the hole has become slightly oblonged. An easy way to make a chuck ready mount for the regular hex bolt is to just thread a piece of aluminum tube, screw the bolt in and lock it with a nut, if the drill can chuck the tube then you can make a taper point on a bench style belt sander or take it to a machine shop and get them to turn a nice wide angle taper point on it. Shouldn't take them more than a few minutes to do that in a fixed 3 jaw lathe chuck. If you are certain you will never use the top screw and just want it 100% sealed, drill and tap the hole for a 3/8-16 bolt, belt sand the tip of the bolt as flat as possible and wrench that thing in there as tight as you can get it. Coat the tip with the highest heat silicone you can get...red or copper I think it the highest and it should seal it. I had to do that with my center screw. The hole did not line up after trying to drill out an old broken screw and redo it, the drill pushed off through the center of the old screw and double cut the original water hole by just the smallest amount, new screws wouldn't seal it at all. Had to plug it with a bolt at that point. The only other option was major work, cut the outside section of the head pipe out entirely to give an access window, weld the inside hole shut, weld the cut out back onto the pipe and redo the entire water injection hole. I wasn't willing to take it to that extent, or willing to send it out to do that either. The bolt works, and has been doing well since, this is about a year now with no further issues.