Here is how I do it (might be wrong dont hold me against it) Just tuned my dual 44s tonight on my fresh motor... in the dark.
to Lean: cutting out no power, sounds like a miss in a car motor
Lean but almost perfect: ALOT of power - this is where good tuners say you get the most HP, but you fry top ends faster
Perfect: less power then the slightly lean setup, good power every where. no hesitation, no cutting out, and it IDLES!!
Too Rich: when u brapp the throttle quickly whether it be on the low or the high it hesitates or "Loads up" with too much fuel, Not a bad thing especially on a newer motor, cuz ur not gonna ruin anything if ur tuning it in, basically giving the pistons a bath lol
I usually start out rich on my adjustments and work my way to perfect, good piece of mind that Im not gonna starve this motor for fuel/oil and lock it up. for instance: these carbs came from a 760 waverunner, going on a ported/bored 701. started at 2 turns out on HI, 1 1/2 turn out on low. ended up with 1 turn out on high, 3/4 on low. Idles good, nice amount of smoke out the tail pipe, no overheating, sounds good, etc.
The absolute best way to do it, and most will agree is with a Tach installed, so you can watch RPMS the motor is putting out
Im sure something im doing might be a little off but it works for me