(This is for Mikuni carbs) If I recall correctly, your adjustment screws should have 3 full turns of adjustment. If you start with a closed screw and open it 3 turns, you have effectively added the same amount of fuel as a half jet size larger, so a 75 jet with 3 turns out on the screw would be a 77.5.
Engine mods like a pipe can drastically effect the fuel needs of a motor, hence the need for jetting changes. For instance, my superjet high jets are 140s with my mods and stock was 130. No way you could get enough fuel just using the adjusters.